6th December

Synthesis of 2-trifluoromethylated piperidines and azepanes


The incorporation of fluorine atom in organic compounds can have a profound impact on the physico-chemical properties and, therefore, on the biological activity of the molecules. Amines possessing an α-trifluoromethyl substituent are thus of great importance in medicinal chemistry, as amines are present in a variety of bioactive compounds. This collection by Sarah Rioton focuses on the different methods allowing the organic synthesis of 2-(trifluoromethyl)piperidines and 2-(trifluoromethyl)azepanes.

Many thanks, Sarah (@s_rioton)!